This happens most often in people who:. If taken during a heart attack, aspirin can significantly reduce the chance of death. On the other hand, it should not be taken if you are having a stroke as strokes may be caused by the rupture of a vein rather than by blockage. As such, aspirin can make a stroke worse by promoting bleeding. Aspirin should be avoided in children with fever due to the risk of Reye's syndrome , which is a form of encephalopathy a brain disease.
Ibuprofen is an NSAID used to treat pain, fever, and inflammation, and is commonly used to alleviate the symptoms of a migraine, menstrual cramps , or rheumatoid arthritis. Combination opioid products containing ibuprofen include:.
This may be better for acute pain, like a new injury. The downside is that ibuprofen has to be taken more often than naproxen. It should be avoided in people with kidney or liver problems and may increase the risk of hypertension high blood pressure and heart attack if taken excessively.
Ibuprofen and all NSAIDs except aspirin may increase your risk of heart attack or stroke, which can happen suddenly and be fatal. Ibuprofen may also cause serious damage to the stomach or intestines, including bleeding, ulcers, or holes.
Naproxen sodium is an NSAID used to treat the same symptoms and conditions as ibuprofen pain, fever, inflammation, migraine, menstrual cramps, rheumatoid arthritis. It's also sometimes used for the painful chronic conditions Paget's disease and Bartter syndrome. Prescription products containing naproxen include:. You also don't have to take it as often. This can make it a better choice if you need to take it regularly for pain from a chronic condition.
Another real advantage is that naproxen sodium is associated with fewer side effects than ibuprofen, meaning it's safer overall and you may be able to tolerate it if ibuprofen bothers you. Compared to ibuprofen, naproxen has a far higher risk of stomach ulcers. As such, it should be taken with food or avoided if you have a history of ulcers or inflammatory bowel disease IBD. Acetaminophen is the OTC pain reliever of choice for people with kidney disease because ibuprofen and naproxen can decrease kidney function and aspirin is associated with bleeding complications.
Even so, if your kidney function is impaired, use acetaminophen sparingly and under the care and supervision of your healthcare provider. You shouldn't take more than one drug from a class at a time because it increases your risk of side effects or overdose.
Acetaminophen is considered the safest OTC pain reliever to take while you're pregnant, but only for short-term use. According to a study by the Centers for Disease Control and Prevention, birth defects were less common when acetaminophen was used during pregnancy than when NSAIDs or opioids were taken.
As with anything you take during pregnancy, be sure to talk to your obstetrician before using it. Acetaminophen is the OTC pain reliever recommended for people taking blood thinners , but even it should only be taken with the knowledge and oversight of your healthcare provider. NSAIDs—and especially aspirin—can prevent clotting, so combining it with blood-thinning medications like Coumadin warfarin can increase your risk of severe and even fatal bleeding.
When choosing the right pain reliever, it's important to look at the side effects and any potential drug interactions. Get advice from your healthcare provider as to which may be the best for you. If you're in the drugstore and need some last-minute advice, particularly if you have medical conditions or take medications of any kind, you can also ask the pharmacist.
Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Hospital for Special Surgery. FDA strengthens warning of heart attack and stroke risk for non-steroidal anti-inflammatory drugs.
Updated June 9, Raging the war against inflammation with natural products. Front Pharmacol. Published Sep 7. Sharma CV, Mehta V. Paracetamol: mechanisms and updates. National Institutes of Health, U. National Library of Medicine: MedlinePlus. Updated May 26, Take a look at this comparison to get a better idea of which one might be better for you. Both drugs work by temporarily preventing your body from releasing a substance called prostaglandin.
Prostaglandins contribute to inflammation, which may cause pain and fever. By blocking prostaglandins, ibuprofen and naproxen treat minor aches and pains from:. This difference may make naproxen a better option for treating pain from chronic conditions. On the other hand, ibuprofen can be used in young children, but naproxen is only for use in children 12 years and older.
Certain forms of ibuprofen are made to be easier for younger children to take. However, the risk of heart and blood pressure-related side effects is greater with naproxen. Do not take more than the recommended dosage of each drug and do not take either drug for longer than 10 days. If you do, you increase your risk of heart and blood pressure-related side effects.
Smoking cigarettes or having more than three alcoholic drinks per day also increases your risk of side effects. Both medications are also available over the counter with high prescription strength versions available as well.
Aleve primarily differs from ibuprofen in its frequency of dosing. The effects of Aleve may last longer than those of ibuprofen. As a result, Aleve can be dosed every 8 to 12 hours while ibuprofen is usually dosed every 4 to 6 hours. Both drugs have similar side effects and drug interactions.
They should not be used with blood thinning medications due to an increased risk of ulcers. Aleve and ibuprofen also need to be used with caution in elderly individuals with kidney or liver problems. This drug vs drug comparison should be discussed with a doctor. The brief overview presented here does not substitute advice from a doctor.
Skip to main content Search for a topic or drug. Aleve vs Ibuprofen: Main Differences and Similarities. By Gerardo Sison, Pharm. Want the best price on Aleve? Tylenol, Advil and Aleve are common pain relievers on drugstore shelves.
While all three medications can help alleviate a child's discomfort, the active ingredient in each drug is different. In Tylenol, it's acetaminophen; in Advil and Motrin, it's ibuprofen; and in Aleve, it is naproxen. Shevaun Doyle , a pediatric orthopedic surgeon at HSS, provides some general information and guidelines about acetaminophen, ibuprofen and naproxen:. No matter which medication is used, Dr.
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